Research blog category

Research Methods

Methodologies and techniques for protein research

2 articles

Aug 12, 2026

Application Note: Using NDSB Reagents in Protein Isolation Workflows

When protein samples lose solubility during isolation, NDSB reagents can be screened as buffer additives to support a more manageable workflow. This application note outlines how NDSB 221, NDSB 195, and NDSB 211 can be evaluated by role in a protein isolation sequence.

Dr. Sarah Johnson Read more

Jun 10, 2026

Application Note: Using SAND and APG in Exploratory Photoreactive Protein Crosslinking Workflows

When researchers need to preserve short-lived protein associations long enough to compare conditions, a photoreactive workflow can be useful as an exploratory method. This application note shows how Sulfosuccinimidyl-2-(m-azido-o-nitrobenzamido)ethyl-1,3'-dithiopropionate (SAND) can be positioned as the primary reagent in that workflow, with p-Azidophenylglyoxal hydrate (APG) used as an example supporting reagent for comparison during method development.

Dr. Sarah Johnson Read more

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